1H-Pyrazole-3-carboxylicacid 5-methyl-(CAS# 696-22-0)
| Awọn aami ewu | Xi - Irritant |
| Awọn koodu ewu | R36 / 37/38 - Irritating si oju, eto atẹgun ati awọ ara. |
| Apejuwe Abo | S26 - Ni ọran ti olubasọrọ pẹlu awọn oju, fi omi ṣan lẹsẹkẹsẹ pẹlu ọpọlọpọ omi ki o wa imọran iṣoogun. S37 / 39 - Wọ awọn ibọwọ ti o dara ati aabo oju / oju |
Ọrọ Iṣaaju
O jẹ agbo-ara Organic pẹlu agbekalẹ kemikali C5H5N2O2. Nigbagbogbo o jẹ alailẹgbẹ si bida okuta kirisita ofeefee.
Apapọ naa ni awọn ẹgbẹ iṣẹ ṣiṣe meji, ọkan jẹ oruka pyrazole ati ekeji jẹ ẹgbẹ iṣẹ ṣiṣe carboxylic acid. O ni solubility iwọntunwọnsi ati pe o jẹ tiotuka ninu omi ati awọn olofo Organic ti o wọpọ. Ẹgbẹ methyl ninu eto rẹ jẹ ki o jẹ hydrophobic.
Gẹgẹbi agbo-ara heterocyclic, 5-methyl-ni ọpọlọpọ awọn iṣẹ iṣe ti ibi. O jẹ lilo pupọ ni iwadii elegbogi ati iṣelọpọ oogun, nigbagbogbo bi ohun elo aise tabi agbedemeji. Awọn ohun elo kan pato pẹlu iṣelọpọ ti Vitamin B1 analogs, awọn ipakokoropaeku, awọn inhibitors plavix (epo kan ti a lo lati ṣe idiwọ idagbasoke ọgbin), ati bii.
Igbaradi, 5-methyl-le ṣee gba nipa didaṣe atomu nitrogen ti iwọn pyrazole pẹlu oluranlowo methylating (fun apẹẹrẹ methyl iodide). Ọna yii ni a ṣe nipasẹ iṣesi N-methylation, ọna ti o wọpọ ni iṣe ti nucleophile ti o baamu pẹlu reagent N-methyl.
