2 4-Dichloro-5-methylpyrimidine (CAS# 1780-31-0)
Ewu ati Aabo
| Awọn aami ewu | C – Ibajẹ |
| Awọn koodu ewu | 34 – Awọn okunfa sisun |
| Apejuwe Abo | S26 - Ni ọran ti olubasọrọ pẹlu awọn oju, fi omi ṣan lẹsẹkẹsẹ pẹlu ọpọlọpọ omi ki o wa imọran iṣoogun. S36 / 37/39 - Wọ aṣọ aabo to dara, awọn ibọwọ ati aabo oju / oju. S45 – Ni ọran ti ijamba tabi ti o ba ni ailara, wa imọran iṣoogun lẹsẹkẹsẹ (fi aami han nigbakugba ti o ṣee ṣe.) S27 - Mu gbogbo aṣọ ti o ti doti kuro lẹsẹkẹsẹ. |
| UN ID | UN 3261 8/PG 2 |
| WGK Germany | 3 |
| TSCA | Bẹẹni |
| HS koodu | 29335990 |
| Kíláàsì ewu | 8 |
| Iṣakojọpọ Ẹgbẹ | III |
2 4-Dichloro-5-methylpyrimidine (CAS# 1780-31-0) Alaye
| Lo | 2, 4-dichloro-5-methylpyrimidine le ṣee lo ni igbaradi ti 2-fluoro-5-trifluoromethylpyrimidine. 2-fluoro-5-trifluoromethylpyrimidine jẹ agbedemeji pataki fun iṣelọpọ ti awọn oogun elegbogi, eyiti a le lo lati ṣajọpọ awọn agbo ogun dihydrofuran oruka ti a dapọ, ati awọn agbo ogun dihydrofuran oruka ti a dapọ le ṣee lo bi G protein pẹlu awọn oluyipada olugba GPR119, fun itọju ti àtọgbẹ, isanraju ati arun dyslipidemia. Ni afikun, 2-fluoro-5-trifluoromethylpyrimidine tun le ṣee lo bi agbedemeji ninu iṣelọpọ awọn oogun fun itọju arun Alzheimer ati schizophrenia. |
| igbaradi | 5-methyluracil 75g (0.59mol), irawọ owurọ oxychloride 236g, triethylamine hydrochloride 16.5g (0.12mol), ti a fi kun si ọpọn ifura, kikan si 100 ℃ ~ 110 ℃, Reflux reaction 5H, tutu si 4248 chloride 1.19mol), ooru itoju lenu 2H. Lẹhin ipari ti iṣesi, irawọ owurọ oxychloride ti gba pada nipasẹ distillation labẹ titẹ ti o dinku, ati distillation labẹ titẹ dinku ni a tẹsiwaju lati gba 88g (0.54mol) ti 2, 4-dichloro-5-methylpyrimidine ni ikore ti 91.5%. |
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