2 4-Difluorobenzoic acid (CAS# 1583-58-0)

Ohun elo

2, 4-difluorobenzoic acid jẹ oogun pataki kan ati agbedemeji ipakokoropaeku, gẹgẹbi 2, 4-difluorobenzoic acid ti wa ni lilo akọkọ lati ṣajọpọ awọn oogun antifungal fluconazole, voriconazole ati oogun pesticide agbedemeji 4-fluorosalicylic acid, agbedemeji oogun 3, 5-difluoroaniline, bbl 2, 4-difluorobenzoic acid tun le ṣee lo ninu omi kristali awọn ohun elo, eyi ti o ni awọn anfani ti iye to gaju ati awọn ifojusọna ọja ti o dara.

Igbaradi

Fi 2, 4-dinitrotoluene ati omi kun si ohun elo ifaseyin, ṣatunṣe pH iye si 7, aruwo ati ooru si 75°C. Potasiomu permanganate, iṣuu magnẹsia sulfate ati ayase gbigbe alakoso ni a fi kun ni awọn ipele. Lẹhin fifi kun, tẹsiwaju lati aruwo ati fesi ni iwọn otutu igbagbogbo fun awọn wakati 3. Àlẹmọ nigba ti gbona ati ki o w awọn àlẹmọ akara oyinbo pẹlu gbona omi. Darapọ mọ filtrate, acidify pẹlu 35% hydrochloric acid si pH 2-3, nọmba nla ti awọn precipitates funfun wa lẹhin ti awọn kirisita ti jẹ precipitated patapata, filtered, fo, recrystallized, ati ki o gbẹ lati gba awọn kirisita funfun bi 2,4-dinitrobenzoic acid . Iwọn ti 2, 4-dinitrotoluene si potasiomu permanganate jẹ 2.4: 1. Ikore ọja ti igbesẹ yii jẹ 90.7%.

fi N, N-dimethylphthalamide sinu apo eiyan, ooru si 100 ~ 110 ℃, ṣaju fun 0.5 ~ 1h. Ṣafikun fluoride potasiomu anhydrous ti o gbẹ labẹ gbigbe ati ki o tọju iwọn otutu ṣaaju fun 0.5-1h. Lẹhin iyẹn, 2, 4-dinitrobenzoic acid ati hexyltrimethylammonium bromide ni a yara fi kun si ọkọ oju-omi ifaseyin ni akoko kan, ati pe alapapo naa tẹsiwaju si 120 ℃, iwọn otutu ti wa ni itọju ati pe a ti tẹsiwaju ipadasẹhin. Lẹhin 7h ti ifaseyin reflux, epo naa ti gba pada nipasẹ distillation, ati lẹhinna omi ifasẹ ti distilled pẹlu nya. Ida ti o gba jẹ emulsion funfun kan. Lẹhin ti o duro fun akoko kan, ida ibi-afẹde epo ni ipilẹ rì si isalẹ, a da omi funfun funfun ti o wa ni apa oke, ati pe epo naa ti tutu lati ṣaju awọn kirisita funfun lati gba ọja robi; ọja robi ti wa ni atunkọ, Filtration Suction, fifọ, ati gbigbe lati gba awọn kirisita funfun ti 2,4-difluorobenzoic acid. Ipin ti iye 2, 4-dinitrobenzoic acid si potasiomu fluoride jẹ 2.7: 1. Ikore ọja ti igbesẹ yii jẹ 72.4%.

Ọrọ Iṣaaju
2,4-Difluorobenzoic acid jẹ ẹya Organic yellow. Atẹle jẹ ifihan si awọn ohun-ini, awọn lilo, awọn ọna igbaradi ati alaye ailewu ti 2,4-difluorobenzoic acid:

Didara:
- Ifarahan: 2,4-Difluorobenzoic acid jẹ okuta funfun ti o lagbara.
- Solubility: O ti wa ni tiotuka ni wọpọ Organic epo bi ethanol, methanol ati methylene kiloraidi.

Lo:
- Awọn ohun elo opiti: O tun le ṣee lo bi ọkan ninu awọn ohun elo aise fun igbaradi ti awọn ohun elo opiti ati awọn fiimu opiti.
- Awọn ohun elo ile-iṣẹ: 2,4-difluorobenzoic acid le ṣee lo ni ile-iṣẹ itanna, awọn aṣọ ati awọn ile-iṣẹ pilasitik pẹlu egboogi-ipata, anti-oxidation and anti-ultraviolet effects.

Ọna:
- 2,4-Difluorobenzoic acid le ṣee gba nipasẹ fluorination ti hydrofluoric acid pẹlu p-methylanisole.

Alaye Abo:
- Nigbati o ba n ṣiṣẹ, eruku yẹ ki o yee lati yago fun ifasimu ati olubasọrọ oju. Ni akoko kanna, awọn ipo atẹgun ti o dara yẹ ki o wa ni itọju.
- Yago fun olubasọrọ pẹlu awọn aṣoju oxidizing ti o lagbara tabi awọn acids ti o lagbara lati yago fun awọn aati ti o lewu