5-Bromo-3-nitro-2-pyridinol (CAS # 15862-34-7)
Ewu ati Aabo
| Awọn koodu ewu | R22 – Ipalara ti o ba gbe R37 / 38 - Irritating si eto atẹgun ati awọ ara. R41 - Ewu ti pataki ibaje si oju R36 / 37/38 - Irritating si oju, eto atẹgun ati awọ ara. R20 - Ipalara nipasẹ ifasimu |
| Apejuwe Abo | S26 - Ni ọran ti olubasọrọ pẹlu awọn oju, fi omi ṣan lẹsẹkẹsẹ pẹlu ọpọlọpọ omi ki o wa imọran iṣoogun. S36 / 37/39 - Wọ aṣọ aabo to dara, awọn ibọwọ ati aabo oju / oju. S36 - Wọ aṣọ aabo to dara. |
| UN ID | 2811 |
| WGK Germany | 3 |
| HS koodu | 29337900 |
| Akọsilẹ ewu | Ipalara |
| Kíláàsì ewu | IKANU |
Alaye itọkasi
| Lo | 5-bromo-2-hydroxy-3-nitropyridine jẹ agbedemeji Organic ti o le ṣee lo lati ṣeto awọn agbo ogun 3-amino-1- (2-oxo-2-- (3’-(trifluoromethyl))-[1,1’-biphenyl ] -4-yl) ethyl) -5- (pyrrole alkyl-1-yl-sulfonyl) pyridin-2 (1H) - ọkan, agbo-ara yii jẹ agbo-ara inhibitory DOCK1. |
| ọna kolaginni | nitric acid (60-61%,3.5mL) ni a fi kun si ojutu (10mL) ti 5-bromopyridine -2 (1H) -ọkan (1.75g,10.1mmol) ni sulfuric acid ni 0 ℃. A gba adalu naa laaye lati jẹ kikan si iwọn otutu yara ati ki o ru fun wakati 3. Awọn adalu lenu ti wa ni dà sinu yinyin omi ati awọn Abajade precipitate ti wa ni gba nipa ase. Abajade ọja ti a fo pẹlu omi ati ki o gbẹ ni igbale, fifun 5-bromo-2-hydroxy-3-nitropyridine (960mg, 43% ikore) bi funfun ti o lagbara. 1H NMR (500MHz, CDCl3) δ:8.57(s,1H),8.26(s,1H). |
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