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5-Fluorouracil (CAS # 51-21-8) Aworan ifihan
  • 5-Fluorouracil (CAS # 51-21-8) 1

5-Fluorouracil (CAS# 51-21-8)

Ohun-ini Kemikali:

Fọọmu Molecular C4H3FN2O2
Molar Mass 130.08
iwuwo 1.4593 (iṣiro)
Ojuami Iyo 282-286 °C (oṣu kejila) (tan.)
Ojuami Boling 190-200 ° C / 0.1mmHg
Omi Solubility 12.2 g/L 20 ºC
Solubility Tiotuka die-die ni ethanol. O fẹrẹ jẹ inoluble ninu chloroform ati tituka ni ojutu iṣuu soda hydroxide.
Ifarahan Funfun tabi funfun-bi kristali lulú
Àwọ̀ funfun
Merck 14.4181
BRN Ọdun 127172
pKa pKa 8.0 ± 0.1 (H2O) (Aidaniloju);3.0 ± 0.1 (H2O) (Aidaniloju)
PH 4.3-5.3 (10g/l, H2O, 20℃)
Ibi ipamọ Ipo 2-8°C
Iduroṣinṣin Idurosinsin. Imọlẹ imole. Ijona. Ibamu pẹlu awọn aṣoju oxidizing lagbara, awọn ipilẹ ti o lagbara.
Ni imọlara Afẹfẹ Sensitive
Atọka Refractive 1.542
MDL MFCD00006018
Ti ara ati Kemikali Properties aaye yo 282-286°C (oṣu kejila)(tan.) Awọn ipo ipamọ Itaja ni 0-5
solubility H2O: 10 mg / milimita, ko o

fọọmu lulú

awọ funfun

omi solubility 12.2g/L 20 oC
Afẹfẹ ifarabalẹ
owo 14.4181
BRN 127172
Lo Fun akàn eto ounjẹ ounjẹ, akàn ori ati ọrun, akàn gynecological, akàn ẹdọfóró, akàn ẹdọ, akàn àpòòtọ ati itọju alakan awọ ara

Alaye ọja

ọja Tags

Awọn koodu ewu R22 – Ipalara ti o ba gbe
R20 / 21/22 - ipalara nipasẹ ifasimu, ni olubasọrọ pẹlu awọ ara ati ti o ba gbe.
R52 - Ipalara si awọn oganisimu omi
R25 – Majele ti o ba gbe
Apejuwe Abo S36 - Wọ aṣọ aabo to dara.
S36 / 37 - Wọ aṣọ aabo ati awọn ibọwọ to dara.
S36 / 37/39 - Wọ aṣọ aabo to dara, awọn ibọwọ ati aabo oju / oju.
S22 - Maṣe simi eruku.
S45 – Ni ọran ti ijamba tabi ti o ba ni ailara, wa imọran iṣoogun lẹsẹkẹsẹ (fi aami han nigbakugba ti o ṣee ṣe.)
S26 - Ni ọran ti olubasọrọ pẹlu awọn oju, fi omi ṣan lẹsẹkẹsẹ pẹlu ọpọlọpọ omi ki o wa imọran iṣoogun.
UN ID UN 2811 6.1/PG 3
WGK Germany 3
RTECS YR0350000
FLUKA BRAND F koodu 10-23
TSCA T
HS koodu 29335995
Akọsilẹ ewu Irritant/Gíga Majele
Kíláàsì ewu 6.1
Iṣakojọpọ Ẹgbẹ III
Oloro LD50 ẹnu ni Ehoro: 230 mg / kg

 

Ọrọ Iṣaaju

Ọja yii ti yipada ni akọkọ si awọn nucleotides 5-fluoro-2-deoxyuracil ninu ara, eyiti o ṣe idiwọ synthase nucleotide thymine ati dina iyipada ti deoxyuracil nucleotides sinu deoxythymine nucleotides, nitorinaa dena biosynthesis DNA. Ni afikun, nipa idilọwọ iṣakojọpọ ti uracil ati rotic acid sinu RNA, ipa ti idinamọ iṣelọpọ RNA ti waye. Ọja yii jẹ oogun kan pato ti iwọn sẹẹli, ni pataki idilọwọ awọn sẹẹli alakoso S.

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