N-(tert-Butoxycarbonyl)-L-aspartic acid (CAS# 13726-67-5)
Ewu ati Aabo
| Awọn aami ewu | Xn – ipalara |
| Awọn koodu ewu | R20 / 21/22 - ipalara nipasẹ ifasimu, ni olubasọrọ pẹlu awọ ara ati ti o ba gbe. R36 / 37/38 - Irritating si oju, eto atẹgun ati awọ ara. |
| Apejuwe Abo | S26 - Ni ọran ti olubasọrọ pẹlu awọn oju, fi omi ṣan lẹsẹkẹsẹ pẹlu ọpọlọpọ omi ki o wa imọran iṣoogun. S36 - Wọ aṣọ aabo to dara. S24/25 - Yago fun olubasọrọ pẹlu awọ ara ati oju. |
| WGK Germany | 3 |
| HS koodu | 2924 19 00 |
N-(tert-Butoxycarbonyl)-L-aspartic acid (CAS# 13726-67-5) Iṣaaju
Boc-L-aspartic acid jẹ ohun elo Organic ti o wọpọ ti a lo bi ẹgbẹ aabo ni iṣelọpọ peptide. Ilana kemikali rẹ jẹ C13H19NO6 ati iwuwo molikula rẹ jẹ 293.29. Boc duro fun N-tert-butoxycarbonyl.
Boc-L-aspartic acid ni akọkọ ni awọn ohun-ini wọnyi:
1. Irisi: lulú kirisita ti ko ni awọ;
2. yo ojuami: nipa 152-155 ℃;
3. Solubility: Soluble ni diẹ ninu awọn olomi-ara, gẹgẹbi dimethyl sulfoxide ati dichloromethane, insoluble ninu omi;
4. iduroṣinṣin: ibajẹ le waye ni ọran ti oxidant ti o lagbara ati ina.
Lilo akọkọ ti Boc-L-aspartic acid jẹ bi ẹgbẹ aabo ni iṣelọpọ peptide. O ṣe aabo fun ẹgbẹ amine lori ẹwọn ẹgbẹ ti L-aspartic acid lati ṣe idiwọ awọn aati aifẹ. Lakoko iṣelọpọ peptide, Boc-L-aspartic acid ṣe atunṣe pẹlu awọn amino acids miiran tabi awọn apakan peptide lati ṣe awọn ẹwọn peptide tuntun. Lẹhin ipari ti iṣelọpọ, ẹgbẹ aabo le yọkuro nipasẹ itọju acid lati gba peptide afojusun tabi amuaradagba.
Boc-L-aspartic acid ni gbogbo igba pese sile nipasẹ awọn ọna sintetiki ti a mọ. Ni ṣoki, L-aspartic acid le ṣepọ nipasẹ didaṣe L-aspartic acid pẹlu t-Boc-L acid ati dimethylformamide. Awọn ọna sintetiki pato ni a le rii ninu awọn iwe kemikali ti o yẹ.
Nipa alaye ailewu, o nilo lati san ifojusi si awọn aaye wọnyi:
1. Boc-L-aspartic acid jẹ nkan ti kemikali pẹlu majele kan. Awọn ọna aabo ti o yẹ yẹ ki o mu lakoko iṣẹ, gẹgẹbi wọ awọn ibọwọ, awọn goggles ati awọn aṣọ yàrá;
2. yago fun inhalation ti lulú tabi ojutu, yago fun olubasọrọ pẹlu ara ati oju;
3. Nigba lilo ati mimu Boc-L-aspartic acid, o yẹ ki o wa ni edidi ati ki o tọju lati yago fun olubasọrọ pẹlu awọn oxidants ati ina to lagbara;
4. Nigbati o ba n ṣe pẹlu egbin Boc-L-aspartic acid, o yẹ ki o sọnu ni ibamu pẹlu awọn ilana agbegbe.
Boc-L-aspartic acid ni akọkọ ni awọn ohun-ini wọnyi:
1. Irisi: lulú kirisita ti ko ni awọ;
2. yo ojuami: nipa 152-155 ℃;
3. Solubility: Soluble ni diẹ ninu awọn olomi-ara, gẹgẹbi dimethyl sulfoxide ati dichloromethane, insoluble ninu omi;
4. iduroṣinṣin: ibajẹ le waye ni ọran ti oxidant ti o lagbara ati ina.
Lilo akọkọ ti Boc-L-aspartic acid jẹ bi ẹgbẹ aabo ni iṣelọpọ peptide. O ṣe aabo fun ẹgbẹ amine lori ẹwọn ẹgbẹ ti L-aspartic acid lati ṣe idiwọ awọn aati aifẹ. Lakoko iṣelọpọ peptide, Boc-L-aspartic acid ṣe atunṣe pẹlu awọn amino acids miiran tabi awọn apakan peptide lati ṣe awọn ẹwọn peptide tuntun. Lẹhin ipari ti iṣelọpọ, ẹgbẹ aabo le yọkuro nipasẹ itọju acid lati gba peptide afojusun tabi amuaradagba.
Boc-L-aspartic acid ni gbogbo igba pese sile nipasẹ awọn ọna sintetiki ti a mọ. Ni ṣoki, L-aspartic acid le ṣepọ nipasẹ didaṣe L-aspartic acid pẹlu t-Boc-L acid ati dimethylformamide. Awọn ọna sintetiki pato ni a le rii ninu awọn iwe kemikali ti o yẹ.
Nipa alaye ailewu, o nilo lati san ifojusi si awọn aaye wọnyi:
1. Boc-L-aspartic acid jẹ nkan ti kemikali pẹlu majele kan. Awọn ọna aabo ti o yẹ yẹ ki o mu lakoko iṣẹ, gẹgẹbi wọ awọn ibọwọ, awọn goggles ati awọn aṣọ yàrá;
2. yago fun inhalation ti lulú tabi ojutu, yago fun olubasọrọ pẹlu ara ati oju;
3. Nigba lilo ati mimu Boc-L-aspartic acid, o yẹ ki o wa ni edidi ati ki o tọju lati yago fun olubasọrọ pẹlu awọn oxidants ati ina to lagbara;
4. Nigbati o ba n ṣe pẹlu egbin Boc-L-aspartic acid, o yẹ ki o sọnu ni ibamu pẹlu awọn ilana agbegbe.
Kọ ifiranṣẹ rẹ nibi ki o si fi si wa
