Boc-Asp-OtBu (CAS# 34582-32-6)

Ọrọ Iṣaaju

Boc-Asp-OtBu, tí a mọ̀ sí Boc-Asp-OtBu, jẹ́ àkópọ̀ ẹ̀rọ alààyè. Atẹle jẹ ifihan si diẹ ninu awọn ohun-ini rẹ, awọn lilo, agbekalẹ ati alaye ailewu:

Iseda:

-Irisi: kirisita ti ko ni awọ tabi awọn nkan powdery.

-Molecular agbekalẹ: C≡H≡NO-7.

-Molecular àdánù: 393.47g/mol.

-yo ojuami: nipa 68-70 ° C.

-Solubility: Soluble ni diẹ ninu awọn olomi Organic, gẹgẹbi dimethylformamide (DMF) ati dichloromethane (DCM).

Lo:

- Boc-Asp-OtBu jẹ ẹgbẹ idabobo ti o wọpọ, ti a lo nigbagbogbo ni iṣelọpọ ti awọn peptides ati awọn agbo ogun amuaradagba. O le daabobo awọn carboxyl ati awọn ẹgbẹ amino ti glutamic acid (Asp) ati ṣe idiwọ awọn aati lairotẹlẹ ati ibajẹ.

Boc-Asp-OtBu tun le ṣee lo bi awọn agbedemeji ifaseyin ni iṣelọpọ Organic, gẹgẹbi ninu iṣelọpọ peptide ati iṣelọpọ oogun.

Ọna Igbaradi:

Ni igbagbogbo, Boc-Asp-OtBu ti pese sile nipa didaṣe amino acid ti o baamu (L-glutamic acid) pẹlu ẹgbẹ aabo tert-butyl (Boc) ati ẹgbẹ aabo tert-butoxycarbonyl (OtBu). Idahun naa ni a gbejade labẹ awọn ipo ti o dara, fun apẹẹrẹ nipasẹ afikun ti activator gẹgẹbi 1- (trimethylsilyl) -1H-pyrazol-3-one (TBTU) tabi N, N'-diisopropylmethylamide (DIPCDI) ninu ohun elo Organic.

Alaye Abo:

- Boc-Asp-OtBu pẹlu kekere oro.

-Nitori pe o jẹ agbo-ara Organic, yago fun eruku simi tabi olubasọrọ pẹlu awọ ara ati oju.

-Nigbati o ba n ṣiṣẹ, o nilo lati tẹle awọn iwọn ailewu yàrá ti o yẹ, gẹgẹbi wọ awọn ibọwọ aabo ati aabo oju.

-Nigbati o ba wa ni ipamọ, o yẹ ki o wa ni itura, ibi gbigbẹ, ati kuro lati ina ati awọn aṣoju oxidizing.

Akoonu ti o wa loke wa fun itọkasi nikan, jọwọ tẹle awọn pato iṣẹ ṣiṣe idanwo kemikali ti o pe nigba lilo ati mimu Boc-Asp-OtBu mu.