BOC-GLY-GLY-GLY-OH (CAS # 28320-73-2)

Ọrọ Iṣaaju

Tert-Butoxycarbonylglycyl glycylglycine (Boc-Gly-Gly-Gly-OH) jẹ agbo-ara Organic pẹlu awọn ohun-ini wọnyi:

Iseda:

-Irisi: maa funfun gara tabi kirisita lulú

-Molecular agbekalẹ: C17H30N4O7

-Molecular àdánù: 402.44g / mol

-Iwọn aaye: nipa 130-132 ° C

-Solubility: Soluble ni Organic solvents bi dimethylformamide (DMF), dichloromethane, chloroform, bbl, insoluble ninu omi.

Lo:

Boc-Gly-Gly-Gly-OH jẹ lilo igbagbogbo ni iṣelọpọ Organic, ni pataki bi idabobo awọn ẹgbẹ tabi awọn ẹgbẹ. O le ṣee lo bi ẹgbẹ aabo ti amino acids lati ṣe idiwọ awọn aati ti kii ṣe pato, ati pe o jẹ lilo ni igbagbogbo ni iṣelọpọ alakoso ti o lagbara, iṣelọpọ peptide ati iṣelọpọ oogun.

Ọna:

Ọna ti o wọpọ fun igbaradi Boc-Gly-Gly-Gly-OH ni lati ṣafihan ẹgbẹ idabobo tert-butoxycarbonyl lori ẹgbẹ carboxyl ti glycine. Awọn igbesẹ kan pato pẹlu:

1. Glycine ti ṣe atunṣe pẹlu adalu iṣuu soda nitrite ati sulfuric acid lati gba tert-butoxycarbonyl glycinate.

2. Ẹgbẹ idabobo Ester ti yọ kuro nipasẹ iṣesi hydrolysis lati gba Boc-glycine.

3. Tun awọn igbesẹ ti o wa loke ṣe lẹmeji lati ṣafihan ẹgbẹ carboxyl ti glycine si awọn ẹgbẹ idabobo tert-butoxycarbonyl meji ni atele lati gba Boc-Gly-Gly-Gly-OH.

Alaye Abo:

Lilo Boc-Gly-Gly-Gly-OH yẹ ki o san ifojusi si awọn ọrọ aabo wọnyi:

-Yẹra fun olubasọrọ pẹlu awọ ara ati oju, nitori o le mu awọ ara ati oju binu.

- Wọ awọn ibọwọ aabo ti o yẹ, awọn goggles ati aṣọ aabo lakoko iṣẹ.

-Ṣiṣẹ ni aaye ti o ni afẹfẹ daradara lati yago fun fifun eruku tabi oru.

- yẹ ki o wa ni ipamọ kuro ninu ina, ooru ati oxidant, tọju apoti ti a fi pamọ, ti a fipamọ sinu itura, ibi gbigbẹ.