BOC-L-Phenylglycine (CAS# 2900-27-8)

Ọrọ Iṣaaju

N-Boc-L-Phenylglycine jẹ ẹya-ara ti o ni imọran ti o ni ipilẹ nipasẹ didasilẹ asopọ kemikali laarin ẹgbẹ amino (NH2) ti glycine ati ẹgbẹ carboxyl (COOH) ti benzoic acid. Eto rẹ ni ẹgbẹ aabo kan (ẹgbẹ Boc), eyiti o jẹ ẹgbẹ tert-butoxycarbonyl, eyiti a lo lati daabobo ifaseyin ti ẹgbẹ amino.

N-Boc-L-phenylglycine ni awọn ohun-ini wọnyi:

- Irisi: White kirisita ri to

Solubility: Soluble ni diẹ ninu awọn olomi Organic, gẹgẹbi dimethylformamide (DMF), dichloromethane, bbl

N-Boc-L-phenylglycine jẹ lilo nigbagbogbo ni awọn aati-igbesẹ pupọ ni iṣelọpọ Organic, paapaa fun iṣelọpọ ti awọn agbo ogun peptide. Ẹgbẹ aabo Boc le ni aabo nipasẹ awọn ipo ekikan, ki ẹgbẹ amino le jẹ ifaseyin ati lẹhinna ṣe awọn aati ti o tẹle. N-Boc-L-phenylglycine tun le ṣee lo bi itọsẹ fun ikole awọn ile-iṣẹ chiral ni iṣelọpọ peptide.

Igbaradi ti N-Boc-L-phenylglycine jẹ pataki nipasẹ awọn igbesẹ wọnyi:

Glycine jẹ esterified pẹlu benzoic acid lati gba benzoic acid-glycinate ester.

Lilo lithium borotrimethyl ether (LiTMP) lenu, benzoic acid-glycinate ester jẹ protonated ati fesi pẹlu Boc-Cl (tert-butoxycarbonyl chloride) lati gba N-Boc-L-phenylglycine.

- N-Boc-L-phenylglycine le jẹ irritating si awọn oju, awọ ara, ati atẹgun atẹgun ati pe o yẹ ki o yago fun lakoko lilo.

- Ohun elo aabo ti ara ẹni gẹgẹbi awọn ibọwọ yàrá, awọn gilaasi aabo, ati bẹbẹ lọ yẹ ki o wọ lakoko iṣẹ.

- O yẹ ki o ṣe ni agbegbe yàrá ti o ni afẹfẹ daradara.

- Yago fun olubasọrọ pẹlu awọn oxidants ati awọn acids ti o lagbara nigbati o tọju.

- Ti o ba gbe tabi ti a fa simu, wa itọju ilera lẹsẹkẹsẹ, mu eiyan ti akopọ, ki o pese alaye aabo to ṣe pataki si dokita.