Boc-L-Tyrosine methyl ester (CAS# 4326-36-7)

Ọrọ Iṣaaju

N-Boc-L-Tyrosine Methyl Ester jẹ akojọpọ kemikali ti orukọ kemikali rẹ jẹ N-tert-butoxycarbonyl-L-tyrosine methyl ester. Awọn ohun-ini rẹ jẹ bi atẹle:

1. Irisi: funfun si grẹy crystalline ri to;

5. Solubility: soluble ni awọn ohun elo ti o ni imọran gẹgẹbi ethanol ati dimethylformamide (DMF), insoluble ninu omi.

N-Boc-L-tyrosine methyl ester jẹ lilo nigbagbogbo ni iṣelọpọ Organic lati daabobo awọn amino acids ninu iṣelọpọ ti awọn agbo ogun polypeptide. O ti wa ni lilo nigbagbogbo bi ẹgbẹ aabo ti L-tyrosine lati ṣe idiwọ awọn aati ti kii ṣe pato ninu iṣesi lati ṣẹlẹ. Ni kete ti iṣesi ba ti pari, ẹgbẹ aabo le yọkuro labẹ awọn ipo ti o yẹ lati gba ọja ibi-afẹde to peye.

Ọna igbaradi ti N-Boc-L-tyrosine methyl ester nigbagbogbo pẹlu awọn igbesẹ wọnyi:

1. Tu L-tyrosine ni dimethylformamide (DMF);

2. Fi iṣuu soda carbonate lati yomi ẹgbẹ carboxyl ti tyrosine;

3. Methanol ati methyl carbonate (MeOCOCl) ti wa ni afikun si adalu ifarahan lati ṣe N-Boc-L-tyrosine methyl ester. Idahun naa ni a maa n ṣe ni awọn iwọn otutu kekere, ati pe apọju ti methyl carbonate ni a lo lati rii daju pe iṣesi naa n wọle.

N-Boc-L-tyrosine methyl ester jẹ iduroṣinṣin diẹ, ṣugbọn o tun nilo lati ni itọju pẹlu iṣọra. Eyi ni alaye aabo gbogbogbo:

1. Yẹra fun olubasọrọ pẹlu awọ ara ati oju: Awọn ibọwọ aabo ti o yẹ ati awọn goggles yẹ ki o wọ lati yago fun olubasọrọ taara pẹlu agbo;

2. Yẹra fun ifasimu: Afẹfẹ ti o dara yẹ ki o rii daju ni agbegbe iṣẹ lati ṣe idiwọ ifasimu ti awọn gaasi agbo;

3. Ibi ipamọ: O yẹ ki o wa ni ipamọ ni itura, ibi gbigbẹ ati yago fun olubasọrọ pẹlu atẹgun, acids lagbara, tabi awọn ipilẹ ti o lagbara.

Iwoye, N-Boc-L-tyrosine methyl ester jẹ agbedemeji pataki ni iṣelọpọ Organic ati pe o ṣe ipa pataki ninu iṣelọpọ ti awọn agbo ogun peptide. Itọju yẹ ki o gba fun iṣẹ ailewu nigba lilo ati mimu.