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D-Glutamine (CAS # 5959-95-5) Aworan ti o ni ifihan
  • D-Glutamine (CAS# 5959-95-5) 1

D-Glutamine (CAS# 5959-95-5)

Ohun-ini Kemikali:

Fọọmu Molecular C5 H10 N2 O3
Molar Mass 146.14
iwuwo 1.3394 (iṣiro ti o ni inira)
Ojuami Iyo 184-185 °C
Ojuami Boling 265.74°C (iṣiro ti o ni inira)
Yiyi pato (α) -32º (589nm, c=10, N HCl)
Omi Solubility 42.53g/L (iwọn otutu ko sọ)
Solubility Tiotuka ninu omi (9 mg / milimita ni 25 °C), DMSO (<1 mg / ml ni 25 °C), ati ethanol (<1 mg / m)
Ifarahan Funfun okuta lulú
Àwọ̀ Funfun
BRN Ọdun 1723796
pKa 2.27± 0.10 (Asọtẹlẹ)
Ibi ipamọ Ipo Tọju ni aaye dudu, Afẹfẹ Inert, otutu yara
Atọka Refractive -33 ° (C=5, 5mol/LH
MDL MFCD00065607
Ti ara ati Kemikali Properties Oju Iyọ: 185
Iwadi in vitro Glutamine jẹ amino acid bọtini kan ninu eto aifọkanbalẹ aarin (CNS), ti n ṣe ipa pataki ninu glutamate/GABA-Glutamine ọmọ (GGC). Ninu GGC, Glutamine ti wa ni gbigbe lati awọn astrocytes si awọn neuronu, nibiti yoo ti kun inhibitory ati awọn adagun-ara neurotransmitter excitatory. A ti lo D-Glutamine lati ṣe iwadi ipa rẹ ni fifun aabo lodi si idalọwọduro ti o fa acetaldehyde ti iṣẹ idena ni monolayer cell Caco-2. Ipa ti L-Glutamine ni aabo ti epithelium oporoku lati idalọwọduro ti acetaldehyde ti iṣẹ idena jẹ iṣiro ni monolayer cell Caco-2. L-Glutamine dinku idinku ti acetaldehyde-induced ni transepithelial itanna resistance ati ilosoke ninu permeability si inulin ati lipopolysaccharide ni akoko kan-ati iwọn-ti o gbẹkẹle ọna; D-Glutamine, L-aspargine, L-arginine, L-lysine, tabi L-alanine ko ṣe idabobo pataki. D-Glutamine tun kuna lati ni ipa idinku acetaldehyde-induced ni TER ati ilosoke ninu ṣiṣan inulin. D-Glutamine tabi inhibitor glutaminase nipasẹ ara wọn ko ni ipa lori TER tabi ṣiṣan inulin ni iṣakoso tabi awọn monolayers sẹẹli ti a ṣe itọju acetaldehyde. Aini ipa ti D-Glutamine ni aabo lati acetaldehyde tọkasi pe aabo ti L-Glutamine-laja jẹ stereospato.

Alaye ọja

ọja Tags

Awọn aami ewu Xi - Irritant
Awọn koodu ewu 36/37/38 - Irritating si oju, eto atẹgun ati awọ ara.
Apejuwe Abo S36 / 37/39 - Wọ aṣọ aabo to dara, awọn ibọwọ ati aabo oju / oju.
S26 - Ni ọran ti olubasọrọ pẹlu awọn oju, fi omi ṣan lẹsẹkẹsẹ pẹlu ọpọlọpọ omi ki o wa imọran iṣoogun.
S27 - Mu gbogbo aṣọ ti o ti doti kuro lẹsẹkẹsẹ.
S24/25 - Yago fun olubasọrọ pẹlu awọ ara ati oju.
WGK Germany 3
HS koodu 29241900

 

Ọrọ Iṣaaju

Awọn isomer atubotan ti glutamine jẹ kosi insoluble ni methanol, ethanol, ether ati benzene.

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