fmoc-O-tert-butyl-D-tyrosine (CAS# 118488-18-9)

Fmoc-O-tert-butyl-D-tyrosine jẹ amino acid ti o ni aabo ti o wọpọ. Atẹle ni apejuwe ti iseda rẹ, lilo, agbekalẹ ati alaye ailewu:

Iseda:
Fmoc-O-tert-butyl-D-tyrosine jẹ kristali funfun ti o lagbara. O jẹ agbo-ara Organic pẹlu agbekalẹ kemikali C30H31NO7 ati iwuwo molikula kan ti 521.57g/mol. Apapọ naa jẹ itọsẹ ti tyrosine ninu eyiti ẹgbẹ amino jẹri ẹgbẹ aabo Fmoc (9-fluorofluorenylformyl) ati pe ẹgbẹ carboxylic acid ti ni itọsi pẹlu O-tert-butyl.

Lo:
Fmoc-O-tert-butyl-D-tyrosine jẹ lilo nigbagbogbo bi amino acid ti o ni aabo ni iṣelọpọ peptide. Nipa sisopọ ẹgbẹ aabo Fmoc si ẹgbẹ amino, awọn aati ẹgbẹ ti aifẹ le ṣe idiwọ lakoko iṣelọpọ. O ti wa ni o gbajumo ni lilo ni ri to alakoso kolaginni ati ki o le ṣee lo lati synthesize polypeptides ati awọn ọlọjẹ.

Ọna Igbaradi:
Igbaradi ti Fmoc-O-tert-butyl-D-tyrosine ni gbogbogbo nipasẹ iṣelọpọ kemikali. Ni akọkọ, tyrosine ṣe atunṣe pẹlu Fmoc-Cl (9-fluorofluorenylcarbonyl chloride) lati ṣe Fmoc-O-tyrosine. Cesium tert-butyl bromide ti wa ni afikun si iṣesi lati ṣe idaniloju ẹgbẹ carboxylic acid lati dagba Fmoc-O-tert-butyl-D-tyrosine. Nikẹhin, ọja mimọ ni a gba nipasẹ awọn igbesẹ ti crystallization, fifọ ati gbigbẹ.

Alaye Abo:
Fmoc-O-tert-butyl-D-tyrosine jẹ agbopọ iduroṣinṣin labẹ awọn ipo deede ati pe ko ni iyipada ti o han ni iwọn otutu yara. Lakoko lilo, o jẹ dandan lati ni ibamu pẹlu awọn ilana aabo yàrá, wọ ohun elo aabo ti o yẹ, ati yago fun olubasọrọ pẹlu awọ ara ati oju. Nigbati o ba n mu tabi titoju, o yẹ ki o wa ni ipamọ ni ibi gbigbẹ, itura ati kuro ni ina ati awọn aṣoju oxidizing. Ni akoko kanna, olubasọrọ pẹlu awọn oxidants lagbara ati awọn acids ti o lagbara yẹ ki o yee lati ṣe idiwọ awọn aati ti o lewu. Wa iranlọwọ iṣoogun lẹsẹkẹsẹ ti jijẹ tabi ifihan lairotẹlẹ si agbo.