Fmoc-L-glutamic acid-gamma-benzyl ester (CAS# 123639-61-2)

Fluorene methoxycarbonyl-L-glutamic acid-Γ-benzyl jẹ agbo-ara Organic ti a lo ninu iṣelọpọ peptide ni iṣelọpọ-alakoso ti o lagbara. Iseda rẹ:
- Irisi: Funfun to bia ofeefee ri to
- Solubility: Fmoc-L-Glu (OtBu) -OH ni solubility ti o dara laarin awọn olomi-ara ti o wọpọ.

Lilo akọkọ ti Fmoc-L-Glu (OtBu) -OH jẹ bi ẹgbẹ aabo ni iṣelọpọ peptide. Nigbati o ba n ṣepọ awọn ẹwọn peptide, Fmoc-L-Glu (OtBu) -OH sopọ mọ awọn amino acids, aabo iṣẹ ṣiṣe wọn lodi si awọn aati ti kii ṣe pato pẹlu awọn ifaseyin miiran. Lẹhin ti iṣesi ti pari, Fmoc-L-Glu (OtBu) -OH le yọkuro nipa yiyọ ẹgbẹ aabo kuro lati mu iṣẹ ṣiṣe ti amino acids pada.

Igbaradi ti Fmoc-L-Glu(OtBu) -OH jẹ idiju pupọ ati ni gbogbogbo nilo lilo lẹsẹsẹ ti awọn igbesẹ iṣelọpọ Organic. Glutamic acid ti ṣe pẹlu bromoacetate lati gba ethyl glutamate. Lẹhinna, ethyl glutamate ti wa ni idahun pẹlu ọti benzyl lati ṣe ester ethyl glutamate benzyl oti. Ethyl glutamate benzyl oti ester ni a ṣe pẹlu Fmoc-Cl lati ṣe agbekalẹ ọja ibi-afẹde Fmoc-L-Glu(OtBu) -OH.

Alaye Aabo: Fmoc-L-Glu(OtBu) -OH jẹ oogun ile-iyẹwu kan ati pe o nilo lati lo labẹ iṣẹ ṣiṣe yàrá ailewu. Tẹle awọn iṣe aabo yàrá gbogbogbo, pẹlu wiwọ ohun elo aabo ti ara ẹni (fun apẹẹrẹ, awọn ibọwọ lab, awọn goggles, ati bẹbẹ lọ), yago fun ifarakan ara ati ifasimu, ati ṣiṣiṣẹ ni ile-iwosan ti o ni afẹfẹ daradara. Agbo yẹ ki o wa ni ipamọ sinu apoti ti afẹfẹ, kuro lati ina ati awọn oxidants.