Fmoc-L-homophenylalanine (CAS# 132684-59-4)
Ewu ati Aabo
| Awọn aami ewu | Xi - Irritant |
| Awọn koodu ewu | 36/37/38 - Irritating si oju, eto atẹgun ati awọ ara. |
| Apejuwe Abo | S22 - Maṣe simi eruku. S24/25 - Yago fun olubasọrọ pẹlu awọ ara ati oju. S44 - S35 - Ohun elo yii ati apoti rẹ gbọdọ wa ni sisọnu ni ọna ailewu. S28 - Lẹhin olubasọrọ pẹlu awọ ara, wẹ lẹsẹkẹsẹ pẹlu ọpọlọpọ ọṣẹ-suds. S7 - Jeki eiyan ni wiwọ ni pipade. S4 – Jeki kuro lati ibugbe. |
| WGK Germany | 3 |
| HS koodu | 2924 29 70 |
| Kíláàsì ewu | IKANU |
Ọrọ Iṣaaju
2. Solubility: Soluble ni Organic solvents bi dimethyl sulfoxide (DMSO) ati ethyl acetate (EtOAc), insoluble ninu omi.
3. molikula agbekalẹ: C32H29NO4.
4. molikula àdánù: 495.58.
Lilo akọkọ ti Fmoc-L-homophenylalanine jẹ bi ẹgbẹ aabo ni iṣelọpọ peptide. Fmoc jẹ abbreviation fun furoyl ati awọn itọsẹ rẹ, eyiti o le daabobo ẹgbẹ amino ninu amino acids. Nigbati o ba fẹ lati ṣajọpọ pq peptide, ẹgbẹ amino le ṣee wa fun iṣesi nipa yiyọ ẹgbẹ aabo Fmoc kuro. Nitorinaa, Fmoc-L-homophenylalanine ṣe ipa pataki ninu igbaradi awọn oogun peptide ati awọn ohun elo bioactive ti o ni ibatan.
Ọna igbaradi ti Fmoc-L-homophenylalanine jẹ idiju pupọ ati pe o kan iṣesi iṣelọpọ-igbesẹ lọpọlọpọ. Ọna igbaradi ti o wọpọ jẹ nipa ifasilẹ phenylalanine ti o ni idaabobo Fmoc pẹlu awọn reagents miiran, gẹgẹbi fadaka azide formate (AgNO2), atẹle nipa itọju trifluoroacetic acid lati fun Fmoc-L-homophenylalanine.
Alaye aabo atẹle yẹ ki o ṣe akiyesi nigba lilo Fmoc-L-homophenylalanine:
1. yago fun olubasọrọ taara pẹlu awọ ara, oju ati awọn membran mucous, nitori pe o le jẹ irritating si ara eniyan.
2. Ibi ipamọ yẹ ki o yago fun olubasọrọ pẹlu awọn oxidants ti o lagbara tabi awọn acids lagbara lati dena awọn aati ti o lewu.
3. Lo awọn ohun elo aabo ti ara ẹni ti o yẹ gẹgẹbi awọn ibọwọ, awọn gilaasi aabo ati awọn ẹwu yàrá nigba lilo ati mimu.
4. Gbogbo awọn iṣẹ yẹ ki o ṣe labẹ awọn ipo yàrá ti o ni afẹfẹ daradara.
Ni akojọpọ, Fmoc-L-homophenylalanine jẹ ẹgbẹ aabo amino acid ti o wọpọ ni iṣelọpọ peptide ati pe o ni ọpọlọpọ awọn ohun elo. Nigba lilo ati mimu agbo, o jẹ dandan lati san ifojusi si ailewu mimu ati ibi ipamọ.
