Methoxymethyl triphenylphosphonium kiloraidi (CAS# 4009-98-7)

Nlo

(Methoxymethyl) triphenylphosphorus kiloraidi ni a lo lati ṣepọ cefaltacin, eyiti o jẹ oogun ọlọjẹ ati egboogi-tumor. O tun lo lati ṣajọpọ ajẹkù ti paclitaxel.

Igbaradi

Ọna kan fun synthesizing (methoxymethyl) triphenylphosphorus kiloraidi, ti o ni awọn igbesẹ wọnyi: labẹ aabo ti nitrogen, fifi 50mL ti acetone anhydrous sinu riakito kan, lẹhinna ṣafikun 32g ti triphenylphosphine, fifa ati igbega iwọn otutu si 37 ° C, mimu iwọn otutu igbagbogbo duro. , fifi 20g ti methyl chloromethyl ether kun si riakito, ati lẹhinna fesi ni 37 ° C fun 3h, laiyara gbe iwọn otutu soke si 47 ° C ni iwọn 1 ° C / min, a ṣe ilọsiwaju fun 3h, a ti da aiṣedeede duro, ati 37.0g (methoxymethyl) triphenylphosphorus chloride ti gba nipasẹ sisẹ, anhydric. ether fifọ ati gbigbe pẹlu ikore ti 88.5%.