Methyl 2-cyanoisonicotinate (CAS# 94413-64-6)
Ewu ati Aabo
| Kíláàsì ewu | 6.1 |
Ọna iṣelọpọ
Apapo ibi-afẹde ti pese sile nipasẹ ifoyina, amidation ati gbigbẹ pẹlu methyl 2-methyl 4-pyridinecarboxylate (2) gẹgẹbi ohun elo ibẹrẹ. eto rẹ jẹ timo nipasẹ 1H NMR ati MS, ati ikore lapapọ jẹ 53.0%. Awọn ipa ti ipin ifunni, iwọn otutu crystallization, akoko ifarahan ati awọn ifosiwewe miiran lori ọja ni a ṣe iwadi nipasẹ awọn idanwo-ifosiwewe kan, ati pe awọn ipo ilana jẹ iṣapeye: n (2): n (potasiomu permanganate) = 1.0: 2.5, iwọn otutu crystallization 0 ~ 5 ℃; n (methyl 2-carboxyl -4-pyridinecarboxylate): n (sulfoxide) = 1.0: 1.4, lenu; iṣesi gbigbẹ gbigbẹ yan eto trifluoroacetic anhydride-triethylamine bi oluranlowo gbigbẹ. Ilana naa rọrun lati ṣiṣẹ, awọn ipo iṣe jẹ ìwọnba, rọrun lati ṣe iwọn iṣelọpọ, ati pe o ni iye ohun elo to wulo.
Lo
Tobisostat ni a lo lati ṣe itọju hyperuricemia onibaje ti gout. Ti a ṣe afiwe pẹlu oogun ibile allopurinol (analopu purine), kii yoo ni ipa lori iṣelọpọ purine ati pyridine ati iṣẹ ṣiṣe henensiamu, ati pe o dinku uric acid Ipa naa ni okun sii, ko nilo iṣakoso atunṣe iwọn lilo nla, ati pe ailewu dara julọ. Methyl 2-cyano-4-pyridine carboxylate jẹ ohun elo aise pataki fun iṣelọpọ ti Tobiso.
