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Mitotan (CAS # 53-19-0) Aworan Afihan
  • Mitotan (CAS# 53-19-0) 1

Mitotan (CAS# 53-19-0)

Ohun-ini Kemikali:

Fọọmu Molecular C14H10Cl4
Molar Mass 320.04
iwuwo 1.3118 (iṣiro ti o ni inira)
Ojuami Iyo 77-78°C(tan.)
Ojuami Boling 405.59°C (iṣiro ti o ni inira)
Omi Solubility <0.1 g/100 milimita ni 24ºC
Solubility DMSO: soluble20mg/ml, ko o
Ifarahan lulú
Àwọ̀ funfun si alagara
Merck 13.6237 / 13.6237
BRN Ọdun 2056007
Ibi ipamọ Ipo Afẹfẹ inert,Iwọn otutu yara
Atọka Refractive 1.6000 (iṣiro)
Ti ara ati Kemikali Properties Yiyo ojuami 76-78 ° C
omi-tiotuka <0.1g/100 milimita ni 24°C
Lo Ọja yii wa fun iwadii imọ-jinlẹ nikan ati pe kii yoo lo fun awọn idi miiran.
Iwadi in vitro Ninu laini sẹẹli TalphaT1 eku, Mitotane ṣe idiwọ ikosile ati yomijade ti TSH, ṣe idiwọ idahun ti TSH si TRH, ati dinku ṣiṣeeṣe sẹẹli, ati fa apoptosis. Ni pituitary TSH-pituitary Asin awọn sẹẹli, Mitotane ko ni dabaru pẹlu homonu tairodu, ṣugbọn taara dinku iṣẹ ṣiṣe ikọkọ ati ṣiṣeeṣe sẹẹli. Mitotane nfa negirosisi cortical adrenal, ibajẹ awo awọ mitochondrial, ati isomọ ti ko ni iyipada si amuaradagba CYP. Mitotane (10-40 μm) ṣe idiwọ basal ati ifasilẹ cortisol ti CAMP ṣugbọn ko fa iku sẹẹli. Mitotane ṣe afihan awọn ipa inhibitory lori basal Star ati awọn ọlọjẹ P450scc. Mitotane (40 μm) dinku ni pataki awọn ipele mRNA ti STAR, CYP11A1 ati cyp21. Mitotane (40 μm) fẹrẹ jẹ imukuro patapata ifakalẹ ti STAR, CYP11A1, CYP17, ati CYP21 mRNA nipasẹ adenosine 8-bromo-cyclic fosifeti. Ni ipele S ti awọn sẹẹli H295R, apapo ti Mitotane ati gemcitabine ṣe afihan antagonism ati idilọwọ pẹlu gemcitabine-mediated inhibition in the cell cycle.
Ni vivo iwadi Ninu awọn eku, Mitotane (60 mg/kg) dinku pataki mitochondrial adrenal ati microsomal “P-450″ ati awọn ọlọjẹ microsomal nipasẹ 34%,55% ati 35%.

Alaye ọja

ọja Tags

Awọn aami ewu Xn – ipalara
Awọn koodu ewu 40 - Ẹri to lopin ti ipa carcinogenic
Apejuwe Abo 36/37 - Wọ aṣọ aabo ati awọn ibọwọ to dara.
UN ID 3249
WGK Germany 3
RTECS KH7880000
HS koodu 2903990002
Kíláàsì ewu 6.1(b)
Iṣakojọpọ Ẹgbẹ III

 

Ọrọ Iṣaaju

Mitotane jẹ agbo-ara Organic pẹlu orukọ kemikali N, N'-methylene diphenylamine. Atẹle jẹ ifihan si awọn ohun-ini, awọn lilo, awọn ọna igbaradi ati alaye ailewu ti mitotane:

 

Didara:

- Mitotane jẹ kristali ti ko ni awọ ti o jẹ tiotuka ninu awọn nkanmimu Organic gẹgẹbi ethanol, ether, ati chloroform.

- Mitotane ni õrùn ti o lagbara.

 

Lo:

- Mitotane ni a lo ni akọkọ fun awọn aati idapọpọ ni iṣelọpọ Organic ati nigbagbogbo lo bi reagent ati ayase.

- O le ṣe alabapin ninu ọpọlọpọ awọn aati kemikali, gẹgẹbi idapọ awọn alkynes, alkylation ti awọn agbo ogun oorun, ati bẹbẹ lọ.

 

Ọna:

- Mitotane le ṣepọ nipasẹ iṣesi-igbesẹ meji. Formaldehyde ti ṣe atunṣe pẹlu diphenylamine labẹ awọn ipo ipilẹ lati ṣe N-formaldehyde diphenylamine. Lẹhinna, nipasẹ pyrolysis tabi iṣesi oxidation iṣakoso, o yipada si mitotane.

 

Alaye Abo:

- Mitotane jẹ agbo-ara irritating ati pe ko yẹ ki o wa si olubasọrọ taara pẹlu awọ ara ati oju. Awọn ohun elo aabo ti o yẹ gẹgẹbi awọn ibọwọ, awọn goggles, ati aṣọ aabo yẹ ki o wọ nigbati o nṣiṣẹ.

- Nigbati o ba tọju ati mimu, ṣe abojuto lati fi idii ati aabo lati ina lati yago fun olubasọrọ pẹlu afẹfẹ ati ọrinrin.

- Mitotane decomposes ni awọn iwọn otutu giga lati ṣe awọn gaasi majele, yago fun alapapo tabi kan si pẹlu awọn nkan ina miiran.

- Tọkasi awọn ilana agbegbe ati tẹle awọn ilana ṣiṣe aabo ti o yẹ nigba sisọnu wọn.

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