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Nicorandil (CAS # 65141-46-0) Aworan ifihan
  • Nicorandil (CAS# 65141-46-0) 1

Nicorandil (CAS# 65141-46-0)

Ohun-ini Kemikali:

Fọọmu Molecular C8H9N3O4
Molar Mass 211.17
iwuwo 1.4271 (iṣiro ti o ni inira)
Ojuami Iyo 92°C
Ojuami Boling 350.85°C (iṣiro ti o ni inira)
Oju filaṣi 230°C
Solubility DMSO:> 10 mg/ml. Tiotuka ninu methanol, ethanol, acetone tabi glacial acetic acid, die-die tiotuka ninu chloroform tabi omi, fere insoluble ninu ether tabi benzene.
Vapor Presure 1.58E-08mmHg ni 25°C
Ifarahan Funfun si funfun-bi kristali lulú
Àwọ̀ funfun si pa-funfun
Merck 14.6521
Ibi ipamọ Ipo 2-8°C
Atọka Refractive 1.7400 (iṣiro)
MDL MFCD00186520
Ti ara ati Kemikali Properties Funfun okuta lulú, odorless tabi die-die odorous, kikorò. Soluble ni methanol, ethanol, acetone tabi acetic acid, die-die tiotuka ninu chloroform tabi omi, diẹ ko ni tu ni ether tabi benzene. Yo ojuami 88,5-93,5 °c. Majele ti o buruju awọn eku LD50 (mg/kg): 1200-1300 ẹnu, 800-1000 iṣọn-ẹjẹ.
Lo Fun idena ti arun ọkan iṣọn-alọ ọkan, angina pectoris
Iwadi in vitro Nicorandil (100 mM) ṣe alekun ifoyina flavoprotein, ṣugbọn ko kan lọwọlọwọ awo ilu, mimu-pada sipo mitoK (ATP) ati awọn ikanni surfaceK (ATP) ni awọn ifọkansi ti o ga ju 10-agbo. Nicorandil dinku iku sẹẹli ni awoṣe granulation ischemic, ipa idaabobo ọkan ti o dina nipasẹ mitoK (ATP) blocker channel 5-hydroxydecanoic acid ṣugbọn kii ṣe nipasẹ surfaceK (ATP). Ipa ti ikanni blocker HMR1098. Nicorandil (100 mM) ṣe idiwọ isonu ti TUNEL positivity, cytochrome C translocation, imuṣiṣẹ caspase-3, ati agbara membran mitochondrial (Delta (Psi) (m)). Onínọmbà ti awọn sẹẹli ti o ni abawọn pẹlu fluorescence Delta (Psi) (m) -itọkasi, tetramethylrhodamine ethyl ester (TMRE) nipasẹ fluorescence mu ṣiṣẹ cell sorter fihan pe, nicorandil ṣe idiwọ Delta (Psi) (m) depolarization ni ọna ti o gbẹkẹle ifọkansi (EC (50) ) to 40 mM, ekunrere 100 mM). Ninu awọn sẹẹli mejeeji ti a ti yipada, Nicorandil ṣiṣẹ atunṣe ailagbara inu, ikanni 80 pS K ti o ni ifamọra glibenclamide. Ninu awọn sẹẹli HEK293T, Nicorandil ṣiṣẹ ni yiyan ikanni K (ATP) ti o ni SUR2B ninu. Nicorandil (100 mM) ṣe idiwọ nọmba awọn sẹẹli ni pataki ni TUNEL-positive ekuro ati alekun 20 mM h2o2-induced caspase-3 aṣayan iṣẹ-ṣiṣe. Idojukọ Nicorandil ṣe idiwọ pipadanu DeltaPsim ti o fa nipasẹ H2O2.
Ni vivo iwadi Nicorandil (2.5 mg / kg lojoojumọ, po) ni apapo pẹlu Amlodipine (5.0 mg / kg ojoojumọ, po) ọjọ mẹta ti iṣe ṣe pataki ni idaabobo awọn iyipada ati iṣẹ-ṣiṣe enzymu mu pada si awọn ipele ti o sunmọ awọn ti awọn eku deede.

Alaye ọja

ọja Tags

Awọn aami ewu Xn – ipalara
Awọn koodu ewu R22 – Ipalara ti o ba gbe
R41 - Ewu ti pataki ibaje si oju
Apejuwe Abo S26 - Ni ọran ti olubasọrọ pẹlu awọn oju, fi omi ṣan lẹsẹkẹsẹ pẹlu ọpọlọpọ omi ki o wa imọran iṣoogun.
S39 - Wọ oju / aabo oju.
WGK Germany 3
RTECS US4667600
HS koodu 29333990
Oloro LD50 ninu awọn eku (mg/kg): 1200-1300 ẹnu; 800-1000 iv (Nagano)

 

Ọrọ Iṣaaju

Nicolandil, ti a tun mọ si nicorandil amine, jẹ agbo-ara Organic. Atẹle jẹ ifihan si awọn ohun-ini, awọn lilo, igbaradi ati alaye ailewu ti nicorandil:

 

Didara:

- Nicorandil jẹ kristali ti ko ni awọ ti o jẹ tiotuka ninu omi ati awọn olomi Organic.

- O jẹ ipilẹ ipilẹ ti o le fesi pẹlu awọn acids lati ṣe agbejade awọn agbo ogun iyọ.

Nicorandil jẹ iduroṣinṣin ni afẹfẹ, ṣugbọn o le jẹjẹ nigbati o ba farahan si awọn iwọn otutu giga.

 

Lo:

- Nicolandil tun le ṣee lo ni iṣelọpọ ti awọn ayase iṣelọpọ Organic, awọn fọtosensitizers, ati bẹbẹ lọ.

 

Ọna:

Nicolandil maa n pese sile nipasẹ iṣesi ti dimethylamine ati awọn agbo ogun 2-carbonyl.

- Ihuwasi naa ni a gbe jade labẹ awọn ipo ipilẹ ati iṣe alapapo ni a ṣe ni epo ti o yẹ.

 

Alaye Abo:

Nicorandil jẹ ailewu ailewu fun eniyan labẹ awọn ipo gbogbogbo.

- Sibẹsibẹ, o yẹ ki o ṣe itọju lati yago fun olubasọrọ taara pẹlu awọn oju, awọ ara, ati eto atẹgun.

- Wọ ohun elo aabo ti ara ẹni ti o yẹ (PPE) gẹgẹbi awọn gilaasi ailewu, awọn ibọwọ ati ohun elo mimi.

- Nigbati o ba nlo tabi titoju nicorandil, o yẹ ki o ṣe itọju lati yago fun ina ati awọn ipo iwọn otutu giga.

 

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