(S)-N-ALPHA-T-BUTYLOXYCARBONYL-PYROGLUTAMIC ACID T-BUTYL ESTER (CAS# 91229-91-3)

Ọrọ Iṣaaju

di-tert-butyl (2S) -5-oxopyrrolidine-1,2-dicarboxylate jẹ agbopọ ti ilana kemikali jẹ C14H23NO6. Atẹle jẹ apejuwe ti awọn ohun-ini, awọn lilo, igbaradi ati alaye ailewu ti agbo:

Iseda:

-Irisi: di-tert-butyl (2S) -5-oxopyrrolidine-1,2-dicarboxylate jẹ awọ ti ko ni awọ si funfun crystalline.

-Solubility: O ti wa ni tiotuka ni Organic epo bi ethanol, methanol ati dimethyl sulfoxide.

-Melting ojuami: Awọn yellow yo ni nipa 104-105 ° C.

Lo:

di-tert-butyl (2S) -5-oxopyrrolidine-1,2-dicarboxylate jẹ itọsẹ amino acid ti o wọpọ, ti a lo nigbagbogbo bi reagent ninu iṣelọpọ Organic. O le ṣee lo lati ṣajọpọ awọn agbo ogun ti nṣiṣe lọwọ biologically, gẹgẹbi awọn oogun ati awọn ohun elo polima.

Ọna:

Igbaradi ti di-tert-butyl (2S) -5-oxopyrrolidine-1,2-dicarboxylate ni a maa n ṣe nipasẹ awọn igbesẹ wọnyi:

1. Tu pyroglutamic acid tert-butyl ester ninu dimethyl sulfoxide gbẹ.

2. Iwọn ti o yẹ ti N, N'-dihydroxyethyl isopropanamide ti wa ni afikun ati pe a ti tutu adalu esi si isalẹ 0 ° C.

3. Ṣafikun di-tert-butyl carbonate laiyara lakoko mimu iwọn otutu ti adalu lenu ni isalẹ 0 ° C.

4. Lẹhin ti pari ti ifasẹyin, a ti fi adalu ifasilẹ sinu omi lati ṣe agbejade ti o lagbara ti di-tert-butyl (2S) -5-oxopyrrolidine-1,2-dicarboxylate.

5. Ọja ikẹhin ni a gba nipasẹ awọn igbesẹ ti crystallization, sisẹ ati gbigbẹ.

Alaye Abo:

di-tert-butyl (2S) -5-oxopyrrolidine-1,2-dicarboxylate yẹ ki o lo ati mu ni ibamu pẹlu awọn iṣe ailewu lati yago fun ifihan si awọ ara, oju ati ifasimu. Ni afikun, o yẹ ki o wa ni ipamọ ni ibi gbigbẹ, itura ati kuro lati ina ati awọn oxidants. Fun alaye aabo kan pato, tọka si Iwe Data Abo Kemikali (MSDS) tabi alaye ti o yẹ ti olupese pese.